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SKIN / misc-articles / Lactoferrin for acne
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  • Chan, H., Chan, G., Santos, J., Dee, K., & Co, J. (2017). A randomized, double‐blind, placebo‐controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris. International Journal of Dermatology, 56. https://doi.org/10.1111/ijd.13607.
  • Mohsen, R., Twab, H., Salem, H., of, D., & Dermatology, A. (2023). Serum Level of Lactoferrin in Patients with Acne Vulgaris and the Efficacy of Lactoferrin Supplementation. The Egyptian Journal of Hospital Medicine. https://doi.org/10.21608/ejhm.2023.325352.
  • Mueller, E. A., Trapp, S., Frentzel, A., Kirch, W., & Brantl, V. (2011). Efficacy and tolerability of oral lactoferrin supplementation in mild to moderate acne vulgaris: an exploratory study. Current medical research and opinion, 27(4), 793–797. https://doi.org/10.1185/03007995.2011.557720
  • Kim, J., Ko, Y., Park, Y., Kim, N., Ha, W., & Cho, Y. (2010). Dietary effect of lactoferrin-enriched fermented milk on skin surface lipid and clinical improvement of acne vulgaris.. Nutrition, 26 9, 902-9 . https://doi.org/10.1016/j.nut.2010.05.011.
  • Kazandjieva J, Dimitrova J, Sankeva M, Yankov D, Bocheva V, Kircheva K, Gincheva V, Gospodinova K, Andasorova R, Milanova M, Jeleva D, Zlateva P, Vasileva I, Yankova R, Gotseva S, Dakova T, Zografova E, Marina S, Kateva M, Broshtilova V, Todeva V, Tsankov N, Mitova Z, Boyanova N, Milani M. Efficacy of a retinoid complex plus anti-inflammatory component cream alone or in combination with prebiotic food supplement in adult acne: A randomized, assessor-blinded, parallel-group, multicenter trial on 184 women. J Cosmet Dermatol. 2022 Nov;21(11):5716-5722. doi: 10.1111/jocd.15074. Epub 2022 May 23. PMID: 35545875.
    • Limitations: Food supplement containing a mixture of prebiotic molecules (FOS&GOS) zinc, lactoferrin, and niacinamide, not just one ingredient
(edited)
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Potential side effects:
  • Generally considered safe, but some reports of stomach cramps and constipation
  • Potential concerns for iron overload in certain individuals
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